The Gimnasia coach had been hospitalised at the start of November, days after celebrating the landmark birthday, after complaining of low spirits and fatigue.
Tests at the La Plata clinic revealed a blood clot on the brain, which doctors later revealed was operated on successfully.
Maradona was subsequently discharged from hospital as an outpatient to continue his convalescence, which he carried out in his dwelling in a private neighbourhood near Tigre, northern Buenos Aires.
But on Wednesday morning he suffered cardiac arrest, and paramedics at the scene failed to revive him.
Maradona began his professional career with Argentinos Juniors at the age of 16 and went on to be considered one of the greatest players ever to step onto a football field.
The diminutive left-footed forward went on to represent Boca Juniors, Barcelona, Napoli, Sevilla and Newell’s Old Boys as a player, and the likes of Racing Club, Dorados, Gimnasia and the Argentina national team later as a coach.